Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil side effects sleep Chloroquine dosage lupus The science behind the innovative, off-label use of this malaria drug, chloroquine, was in large part built in the lab of Andrew Thorburn, PhD, deputy director of the CU Cancer Center, where. Mar 07, 2006 Chloroquine may improve mid-term survival when given in addition to conventional therapy for glioblastoma multiforme. These results suggest that larger, more definitive studies of chloroquine as adjuvant therapy for glioblastoma are warranted. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Glioblastoma chloroquine Glioblastoma Treatment Breakthrough 'Untreatable' Brain., Chloroquine for Glioblastoma Multiforme Annals of Internal. What is hydroxychloroquine side effects Chloroquine, a clinically approved antimalaria drug, has been studied in a randomized glioblastoma trial combining chloroquine with conventional treatment with a benefit not quite significant 45. Currently more than 20 phase I/II cancer clinical trials involving chloroquine or hydroxylchloroquine are open nationwide 24. Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and.. Re-purposing Chloroquine for Glioblastoma Potential.. Chloroquine for Glioblastoma Multiforme Annals of.. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in. G chloroquine phosphate 600 mg base orally once a day for 2 days, followed by 500 mg chloroquine phosphate 300 mg base orally once a day for at least 2 to 3 weeks Comments -Treatment is usually combined with an effective intestinal amebicide. Researchers have observed that chloroquine can make it more difficult for some cells to develop genetic mutations and have hypothesized that chloroquine might prevent glioblastoma cells from developing the mutations that cause them to become resistant to standard treatment. Early studies done in rats support this hypothesis.