Chloroquine resistant malaria

Discussion in 'Canada Drugs Online' started by rearranger, 08-Mar-2020.

  1. RomaKVN XenForo Moderator

    Chloroquine resistant malaria


    Plasmodium species are transmitted by the bite of an infective female mosquito. Occasionally, transmission occurs by blood transfusion, organ transplantation, needle sharing, nosocomially, or from mother to fetus.

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    Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. ANSWER Chloroquine-resistant malaria has been observed in India and so the first line drug of choice should be an artemisinin-derivative in combination with another drug this group of medications are more generally known as "artemisinin-based combination therapies" or ACTs. In addition, physicians treating malaria acquired in Haiti should be aware of the possibility of chloroquine-resistant infections. Patients with persistent fever despite treatment and infected travelers reporting adherence to chloroquine prophylaxis should be treated with alternate antimalarial drug therapy.

    Travelers going to malaria-endemic countries are at risk for contracting the disease, and almost all of the approximately 1,700 cases per year of malaria in the United States are imported. Malaria is a major international public health problem; 91 countries reported an estimated 216 million infections and 445,000 deaths in 2016, according to the World Health Organization (WHO) World Malaria Report 2017.

    Chloroquine resistant malaria

    Chloroquine Dosage Guide with Precautions -, Chloroquine-Resistant Malaria

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  5. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin!

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    This deficiency explains the reduced ability of chloroquine-resistant parasites to concentrate chloroquine, and it suggests that chloroquine resistance is due to a decrease in the number, affinity, or accessibility of chloroquine receptor sites on a constituent of the malaria parasite. Mefloquine is one of the oldest chloroquine-resistant falciparum Malaria pills developed during the Vietnam War. It is taken weekly starting the week before you arrive in the risk area, and for four weeks after leaving the area. However, Mefloquine is not often prescribed by travel doctors because of its side effects. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. 1 Chloroquine. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine.

     
  6. karkaz XenForo Moderator

    Polymyalgia rheumatica (sometimes referred to as PMR) is a common cause of widespread aching and stiffness that affects adults over the age of 50, especially Caucasians. Polymyalgia rheumatica vs late-onset rheumatoid arthritis. Hydroxychloroquine for PMR instead of prednisolone. Mechanism of action of hydroxychloroquine as an antirheumatic.
     
  7. Vlad187 New Member

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Chloroquine Dosage Guide with Precautions - What is Chloroquine Phosphate? - GoodRx CHLOROQUINE sulfate or phosphate oral - Essential drugs
     
  8. Kirg164 Moderator

    Chloroquine Indications, Side Effects, Warnings - A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs
     
  9. Don Julio Well-Known Member

    Chloroquine - Wikipedia Pregnancy. Chloroquine has not been shown to have any harmful effects on the fetus when used for malarial prophylaxis. Small amounts of chloroquine are excreted in the breast milk of lactating women. However, because this drug can be safely prescribed to infants, the effects are not harmful.

    Chloroquine for Malaria in Pregnancy - Full Text View.