It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Sore bum with hydroxychloroquine Is plaquenil a steroid Plaquenil is the most common antimalarial drug given to treat lupus, and most physicians with experience in lupus agree that antimalarial treatments should be used long-term, year-after-year in all patients who can tolerate them. Learn why treatments that were developed for malaria are now used for lupus. Read the study Safety of Long term use of Hydroxychloroquine Therapy Further Verified for People with Lupus. Hydroxychloroquine Plaquenil® was approved by the Food and Drug Administration for symptoms of lupus. The greatest concern people with lupus have when taking hydroxychloroquine is related to vision and an increase in risk for retinal damage. Safety of Long term use of Hydroxychloroquine Therapy Further Verified for People with Lupus Hydroxychloroquine Plaquenil® was approved by the Food and Drug Administration for symptoms of lupus. The greatest concern people with lupus have when taking hydroxychloroquine is related to vision and an increase in risk for retinal damage. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Long term plaquenil therapy Lupus Medications and Treatments, Safety of Long term use of Hydroxychloroquine Therapy. Hydroxychloroquine aps Plaquenil hydroxychloroquine. interact with acetaminophen, cancer medications, tuberculosis medications, birth control pills or hormone replacement therapy, arthritis medications, ACE inhibitors. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Safety of Long term use of Hydroxychloroquine Therapy Further Verified.. Ocular Changes Induced by Long-Term Hydroxychloroquine Plaquenil Therapy. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Plaquenil can be dangerous to children, who are particularly sensitive to the drug. Kids shouldn't take Plaquenil as a long-term treatment. Overdose can be fatal in children. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. but it may be used for long-term treatment of.