White blood cells (also called leukocytes) are part of the immune system, and they are the cells that protect your body against infections by bacteria, viruses, fungi, and parasites. The microorganisms that cause diseases are literally everywhere, but most people do not get sick because they have ample numbers of white blood cells providing protection. Low white blood cell count is also known as leukopenia. Low white blood cell count often means there is a problem in the body, so it is not considered normal. Each has their own specialized purposes and different life spans. Doses of hydroxychloroquine Chloroquine inhibits Plaquenil and retinal damage Canyou take benadryl and plaquenil together Summary White blood cell count decreased is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have High blood pressure. Continued Follow-up Tests. If there's no clear reason for a low white blood cell count, your doctor will probably want to do the test again, or do a differential or "diff" along with the CBC. ANSWER A low white blood cell count almost always is related to a decrease in a type of infection-fighting white blood cell called neutrophils. When you have a low level of neutrophils, the condition is known as neutropenia. There are many causes of neutropenia, and some medications can lead to this problem. Our body produces millions of different white blood cells continuously that replace worn out or dead ones. There are monocytes (morphs into other white blood cells), lymphocytes (releases antibodies, regulates immunity, and kills infected human cells), basophils (initiates inflammatory reactions), eosinophils (kills parasites and triggers allergic reactions), and neutrophils (main killers of bacteria and fungi). Can hydroxychloroquine cause low white blood cell count Low White Blood Cell Count - Symptoms and Diagnosis, Low White Blood Cell Count 6 Possible Causes for a Low WBC Plaquenil and night sweatsHydroxychloroquine and stomach painChloroquine treatment method Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Dugan on plaquenil and low wbc This drug can effect the bone marrow and make the white blood count and platelets low. Your doctor may want to stop this medication, but don't stop it till you talk to the doctor. Plaquenil and low wbc - Things You Didn’t Know. Mayo Clinic Q and A What causes low white blood cell count?. Common and Rare Side Effects for Hydroxychloroquine Oral. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Individuals may suffer from aplastic anemia, a condition where the body is unable to produce new blood cells. Vitamin or mineral deficiencies, influenza, typhoid fever, and malaria can also result in a low white blood cell count. Underlying causes for a low white blood cell count can range from benign disorders, such as vitamin deficiencies, to more serious blood diseases, such as leukemia or lymphoma. A truly low white blood cell count also puts you at higher risk for infections — typically bacterial infections.