Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Plaquenil (hydroxychloroquine) with all of your drugs and health problems. How does hydroxychloroquine treat lupus Plaquenil cross eyes Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria. Lupus arthritis causes pain, stiffness, swelling, tenderness and warmth in your joints. The joints most often affected are the ones farthest from the middle of the body, such as fingers, wrists, elbows, knees, ankles and toes. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain For all uses of Plaquenil (hydroxychloroquine): WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Can plaquenil cause swelling Hydroxychloroquine Plaquenil, How Lupus Affects the Muscles, Tendons and Joints Lupus. Hydroxychloroquine treats what infxEye exam for plaquenilChloroquine solubility dmsoPharmacokinetics of quinine chloroquine and amodiaquine One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The Risk of Retinal Toxicity with Plaquenil. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. BRAND NAMES Plaquenil. Medication Uses How To Use Side Effects Precautions Drug Interactions Overdose Notes Missed Dose Storage. USES Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. Swelling-Usually in the legs, feet, or ankles edema Dark Urine; High Blood Pressure; Changes in Frequency of Urination; Vomiting ; Water Retention/ Weight Gain; In summary Plaquenil isn't causing tyour new problems. It probably caused only the nausea, diarrhea, stomach cramps, and intense vertigo. When the left ankle swelledup, it is the one with the worst vitiligo hyperpigment and lump, and the left side of my heart had some atrophy that my recent cardiologist could not find, though I have an irregular heart beat on the left side, off the plaquenil, my leg very nearly turned blue when it swelled and it was cold.