Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Treatment of uncomplicated malaria chloroquine Chloroquine tablet 500mg Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy. Key words included 'chloroquine', 'cancer', and 'autophagy'. The publication date was up to June 2015. RESULTS Chloroquine mainly executes its anti-tumor function through inhibition of autophagy. It can accumulate inside the lysosome resulting in lysosomal membrane permeabilization LMP which will eventually lead to apoptosis. Here we have tested the effects of inhibitors of autophagy such as chloroquine, on the response to low concentrations of tetrandrine in cancer cells. Experimental Approach. Cultures of several cancer cell lines, including Huh7, U251, HCT116 and A549 cells, were exposed to tetrandrine, chloroquine or a combination of these compounds. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine cancer 2015 Chloroquine - Wikipedia, The utility of chloroquine in cancer therapy. Hydroxychloroquine swollen lymph nodesPlaquenil and swollen lymph nodes This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Chloroquine Indications, Side Effects, Warnings -. Synergistic anti-tumour effects of tetrandrine and chloroquine.. Dissecting pharmacological effects of chloroquine in cancer.. Nov 15, 2015 Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Key words included ‘chloroquine’, ‘cancer’, and ‘autophagy’. The publication date was up to June 2015. ResultsChloroquine mainly executes its anti-tumor function through inhibition of autophagy. It can accumulate inside the lysosome resulting in lysosomal membrane permeabilization LMP which will eventually lead to apoptosis. Chloroquine is a lysosomotropic agent that inhibits auto-lysosomal clearance and it has been previously described that in combination with other chemotherapeutic agents, Chloroquine enhances their anti-cancer effects in several tumor types 21, 22. Hence, we have evaluated the effect of Chloroquine treatment in both primary PDAC derived cells and CAFs.