Chloroquine mechanism of drug action and resistance in plasmodium falciparum

Discussion in 'Canadian Pharmacies Online' started by astred, 22-Feb-2020.

  1. shelter Well-Known Member

    Chloroquine mechanism of drug action and resistance in plasmodium falciparum


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    However, drug resistance threatens to derail this progress. In this review, we present four antimalarial resistance case studies that differ in timeline, technical approaches, mechanisms of action, and categories of resistance chloroquine, sulfadoxine-pyrimethamine, artemisinin, and piperaquine. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of drug action and resistance in plasmodium falciparum

    MECHANISMS OF DRUG RESISTANCE IN PLASMODIUM FALCIPARUM.io=, Chloroquine phosphate C18H32ClN3O8P2 - PubChem

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  5. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - Prescription Drug Information..
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    • Chloroquine Mechanism of drug action and resistance in..

    CHLOROQUINE SENSITMTY IS CONFINED TO PARASITE STAGES V~I-IICH DEGRADE HEMOGLOBIN Early clinical investigations of the antimalarial activities of chloroquine, quinacrine and the cinchona alkaloids noted that drug action in each case was limited to those stages of the parasite Chloroquine in Plasmodium falciparum 209 life cycle which were actively degrading hemoglobin refer to Fig. 2 for a diagrammatic representation of the intraerythrocytic development cycle of malaria parasites. We believe that our results, besides shedding light on the mechanism of chloroquine resistance in P. falciparum, have implications for the development of novel therapies against resistant malaria strains and demonstrate the usefulness of an approach combining systems biology strategies with structural bioinformatics and experimental data. Studies in several West African countries, as well as a recent assessment of drug susceptibility of P. falciparum infections in western and central Zaire, have failed to demonstrate chloroquine-resistance 5.

     
  6. sharf Guest

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  7. serg19 Moderator

    Hydroxychloroquine Oral Tablet 200Mg Drug Medication Dosage. HYDROXYCHLOROQUINE hye drox ee KLOR oh kwin is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. Similar Brand Name Drugs Plaquenil Oral tablet 200mg CVS Pharmacy Patient Statistics for Hydroxychloroquine Oral tablet200mg

    Hydroxychloroquine Oral Uses, Side Effects, Interactions.
     
  8. Lix Guest

    Atovaquone-Proguanil - Side Effects, Dosage, Interactions. Atovaquone and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body. psites that cause malaria typically enter the body through the bite of a mosquito.

    Atovaquone/Proguanil - an overview ScienceDirect Topics