Chloroquine and pancreatic cancer

Discussion in 'Canadian Pharmacies' started by Kotovskii, 21-Feb-2020.

  1. vova07 New Member

    Chloroquine and pancreatic cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Dr. Kimmelman and colleagues were able to display that chloroquine and its derivative, hydroxychloroquine, could block the growth of pancreatic cancer cells in a dish. Other cell types that do not depend on autophagy were unaffected by chloroquine treatment. Pancreatic cancer is extremely resistant to most treatments, which accounts for the low survival rate. "The study provides evidence that using chloroquine in combination with Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine and pancreatic cancer

    Pancreatic Cancer - Moon Shots Program MD Anderson Cancer., New drug combo shows promise against pancreatic cancer.

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  7. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Balic A1, Sørensen MD2, Trabulo SM3, Sainz B Jr1, Cioffi M1, Vieira CR1, Miranda-Lorenzo I1, Hidalgo M4, Kleeff J5, Erkan M5, Heeschen C6.

    • Chloroquine targets pancreatic cancer stem cells via..
    • Combination of ERK and autophagy inhibition as a treatment..
    • Lysosome inhibition sensitizes pancreatic cancer to..

    Mar 20, 2019 Pancreatic cancer the cancer cells are seen here is the third leading cause of cancer-related deaths in the United States. Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers. Jul 15, 2014 Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Conclusion Autophagy blockage with chloroquine or similar-acting drugs may serve as a viable therapy for highly metastatic pancreatic cancers. INTRODUCTION For the past decade the incidence of pancreatic cancer has increased by about 1.5% per year; it is currently the fourth leading cause of cancer death in the United States 1.

     
  8. guron Guest

    I have been on the plaquenil 200 mgm for about 4 months now. Hydroxychloroquine – what you can expect when starting. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire Your RA is in Remission! Now What? Arthritis Foundation
     
  9. crag Moderator

    Hydroxychloroquine Plaquenil Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet.

    Plaquenil - Side Effects, Uses, Dosage, Overdose.