See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Plaquenil rash Plaquenil time to take effect Apo-hydroxychloroquine 2oomg Is chloroquine safe during pregnancy Methotrexate vs plaquenil side effects long term and short term Nov 3, 2009 I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. I started methotrexate over a month ago because the plaquenil I have been on for over a year seemed to stop working for my joint pain. After trying several NSAIDS, my rheumie put me on low dose prednisone and added the methotrexate. I've read that methotrexate may not be good to take for the long term. Has anyone heard this? Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Compare Methotrexate vs Plaquenil - Define 4 hydroxychloroquineIs 200 milligrams of hydroxychloroquine highPlaquenil for oral lichen planusEye exam for plaquenilPolymyalgia rheumatica plaquenil Methotrexate is contraindicated in pre-existing liver conditions; making it necessary to notify your doctor of any pre-existing liver problems. Liver complications and even liver failure are possible long-term side effects of the drug. Long-Term Effects of Methotrexate Healthy Living. Bone Joint Muscle - Arthritis Methotrexate and long term use. Methotrexate side effects - Arthritis Information. Too many side effects of both methotrexate and Hydrochloroquine prompted my beautiful daughter to encourage me to go on a strict diet with no meds. I did check with my gp and rheumy re this. I am now thank God in remission 🌸 Methotrexate Rasuvo, Otrexup is a self-injectable solution used to treat psoriasis and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks.