Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil cause weight gain Hydroxychloroquine painkiller Plaquenil enlarged spleen Hydroxychloroquine plaquenil side effevts Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Chloroquine also obviously weakened the repair of radiation-induced DNA damage. A combination of radiation and chloroquine enhanced the apoptosis rate of EJ and T24 cells and down-regulated the expression of Bcl-2 while up-regulating the expression of caspase-3. Jan 27, 2010 Chloroquine CQ, traditionally used as an antimalarial medication, has emerged as a prospective adjunct in tumor therapy. CQ has been found to strongly potentiate the inhibitory effect of radiation on cancer cell proliferation, presumably via negative regulation of DNA repair processes. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine apoptosis Chloroquine diphosphate, apoptosis and autophagy inhibitor., Chloroquine Enhances the Radiosensitivity of Bladder Cancer. Generic.plaquenil watsonPlaquenil annual eye exam Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. CST - Chloroquine. Chloroquine-induced autophagic vacuole accumulation and cell.. Chloroquine inhibits autophagy and deteriorates the.. The aim of this study is to investigate the effects and mechanism of chloroquine CQ on the apoptosis induced by cisplatin in human gastric cancer BGC823 cells. MTT assay was used to detect the state of cell growth. The appearances of cellular apoptosis were detected by laser scanning confocal microscopy and light microscopy. The expressions of LC3 and p62 were detected by laser scanning. Chloroquine CQ and hydroxychloroquine HCQ, two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. Chloroquine CQ, an anti-malarial drug, has immune-modulating activity and lysosomotropic activity. In this study, we investigated CQ sensitizes TRAIL-mediated apoptosis in human renal cancer Caki cells.