Use of chloroquine during pregnancy

Discussion in 'Chloroquine Phosphate' started by Artich, 03-Mar-2020.

  1. buysssut Moderator

    Use of chloroquine during pregnancy


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Dec 14, 2011 During early pregnancy, treatment options are limited, especially in regions with drug resistance. In a retrospective study covering a 25-year period 1986–2010, investigators compared outcomes between women with a single episode of malaria during the first trimester and women without malaria during pregnancy. Pregnancy. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women; usage during pregnancy should be avoided except in prophylaxis or. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Use of chloroquine during pregnancy

    CHLOROQUINE PHOSPHATE, USP, Aralen, Chloroquine phosphate chloroquine dosing.

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  6. For P. vivax or P. ovale infections, primaquine phosphate and tafenoquine for radical treatment of hypnozoites should not be given during pregnancy. Pregnant patients with P. vivax or P. ovale infections should be maintained on chloroquine prophylaxis for the duration of their pregnancy.

    • Treatment of Malaria Guidelines For Clinicians United..
    • Aralen chloroquine Malaria Drug Side Effects & Dosage.
    • Chloroquine DermNet NZ.

    Dosages Chloroquine 1,500 mg base over 3 days twice during pregnancy or Chloroquine 600 mg loading dose followed by 300 mg orally once per week. Intermittant preventative treatment in pregnancy IPTp doses will be administered between weeks 20-28 and weeks 28-34 gestation, 4 weeks apart. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue deposition and increased risk of retinal toxicity and of fetal Azithromycin-chloroquine is a potential alternative to SP for use in IPTp. The combination has demonstrated synergism in vivo against P. falciparum in India. Preliminary results of studies in non-pregnant adults in sub-Saharan Africa have shown that azithromycin-chloroquine is not inferior to mefloquine, a compound currently under consideration for IPTp.

     
  7. EHOT New Member

    Group: antimalarial agent Tablet 100 mg, 150 mg, 300 mg base (as phosphate or sulfate) Syrup 50 mg base (as phosphate or sulfate) in 5 ml Injection 50 mg, 100 mg base (as phosphate or sulfate) per ml in 2-ml ampoule [chloroquine base 150 mg is equivalent to chloroquine sulfate 200 mg or Chloroquine phosphate 250 mg] General information Policy regarding the use of this drug as an antimalarial must be determined nationally since in many areas P. It may still be used effectively, however, in areas where low-grade P. If part or all of a dose is vomited, the same amount must immediately be readministered. Chloroquine - Uses, Dosage, Side Effects, Composition & more. Chloroquine Oral Route Proper Use - Mayo Clinic WHO Model Prescribing Information Drugs Used in Parasitic.
     
  8. pierrevk Guest

    A case report of hearing loss post use of hydroxychloroquine. Hydroxychloroquine HQ, a quinoline compound, rarely causes ototoxicity. Its ototoxicity is associated with varying degree of destruction of the cochlear sensory hair cells, a decrease in neuronal population, alteration in supporting structures and atrophy and vacuolization of the stria vascularis as a possible consequence of ischemia 1, 2.

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