Why chloroquine is given in loading dose

Discussion in 'Discount Prescription Drugs From Canada' started by Anima, 25-Feb-2020.

  1. Arabeska XenForo Moderator

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Excretion of Chloroquine is quite slow,but is increased by acidification of the urine. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Loading Drug Dose - an overview ScienceDirect Topics, Chloroquine - FDA prescribing information, side effects and uses

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  5. For the treatment of RA, hydroxychloroquine is typically taken by mouth once daily at 200-400 mg, although it can be taken at a higher dose. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity.

    • Hydroxychloroquine Plaquenil -.
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    If a diabetic patient being treated with an oral hypoglycemic agent,develops dilutional hyponatremia-which one of the following could be responsible for this effect Some medicines need to be given at high initial doses loading doses at the start of treatment, before being reduced to a lower, maintenance dose. Reasons vary for the need for loading doses. In some patients the therapeutic level is needed very quickly—for example, phenytoin to stabilise a patient after a seizure. Where complete treatment of severe malaria is not possible but injections are available, give adults and children a single intramuscular dose of artesunate, and refer to an appropriate facility for further care. Where intramuscular artesunate is not available use intramuscular artemether or, if that is not available, use intramuscular quinine.

     
  6. RusTurist Guest

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. FDA grants regular approval to dabrafenib and trametinib. Phase I Study of Trametinib and Hydroxychloroquine in. Phase Ib/II study of hydroxychloroquine in combination.
     
  7. INTELigent Guest

    Too Little of a Good Thing Hydroxychloroquine in Pregnancy. Women with rheumatic diseases, including inflammatory arthritis and systemic lupus erythematosus SLE, fare better in pregnancy when their disease is under good control1,2. The role of hydroxychloroquine HCQ for achieving this control is now recognized. Several studies demonstrate that patients with SLE who continue HCQ during pregnancy have decreased flares and improved pregnancy outcomes.

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