Rheumy says I can take them together or separately anytime I want. Hope that you won't suffer from the side effects. I have found that for me i can't take my Plaquenil before bed as it makes me anxious and makes it difficult to sleep. I’m thinking I’ll take them both together before bed. TIAI took them with breakfast but the first 6 weeks I suffered from extreme nausea as a side effect. I work overnights, so I take it before i go to work, then by the time I get home I am able to sleep ok. Plaquenil and vitamins Chloroquine cytotoxic hemozoin falicparum Is plaquenil used for rheumatoid arthritis Of all the drugs I've had to take for lupus, plaquenil is probably the most mellow. It is my understanding that if it affects your eyes, it's a slow onset type thing, so if you're having your eyes checked regularly every 6mos, you will be fine. Children taking this medication for a long period of time may experience permanent damage to their vision and other side effects. How to take hydroxychloroquine All possible dosages and forms may. Re best time to take plaquenil. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months. One thing I have noticed, is mosquitoes tend not to target me, and I'm wondering if they taste the same yucky quinine flavor, and like us, aren't down with it. :)As for my routine, I took it at night, with or without food. I've had success taking it with a glass of milk, which is recommended on my perscription. I can get an upset stomach if I don't take them with milk or food right before. I always take it with food though, as it makes me nauseous otherwise. Almost 30 years, and it hasn't given me a speck of trouble, not even in the eyes. Best time to take plaquenil Hydroxychloroquine Plaquenil, Hydroxychloroquine Side Effects, Dosage, Uses, and More Cas number chloroquine Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions.. Best time to take plaquenil - HealthBoards Message Boards. Plaquenil Uses, Dosage & Side Effects -. Like the others have said it's best not to take meds prescribed for reflux, such as Omeprazole or Lanzoprazole, at the same time as Plaquenil as they can make it less effective. I need to leave at least a couple of hours between my morning Lanzoprazole and my first dose of Plaquenil otherwise I feel sick. I've been on plaquenil for at least 15 years and from what i can remember it took about 6 months before i realized it was helping. now the best way to tell if its helping me is if i stop taking it, then i can REALLY tell. the pain is much worse along with the fatigue. plaquenil doesn't make it all go away but if i don't take it, it all comes. Talk to your doctor about the best way to treat low blood sugar. Hydroxychloroquine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever.