I couldn't tolerate the generic, but the brand name has a coating for the stomach. Wallace's book and found the stats, plus my rheumie telling me much the same, that many people with lupus (something like 40% or more) "present" with GI problems. Meaning long enough to start to sort out whether your problems were mainly from the disease or from the med? Antimalarial drugs plaquenil Side effects from plaquenil on eye Substitutes and alternatives to Plaquenil hydroxychloroquine for uses like Rheumatoid arthritis, Lupus and Malaria Plaquenil hydroxychloroquine Alternatives & Similar Drugs - Skip to full site navigation Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms. Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. I had to get off of plaquenil as well b/c of toxicity and benign tumors behind my eyes. Hi there, I normally post on the arthritis board, and due to toxicity of the Plaquenil after 2 years, I have had to discontinue it, since I failed the visual field testing. I'm sure you do feel like you're losing your mind.(((hugs)))Pat Hi there, I had put a posting about this a few weeks ago on here. Best alternative to plaquenil Alternative" to plaquenil. ProHealth Fibromyalgia, ME., Compare Plaquenil vs Methotrexate - Chloroquine phosphate user reviewsPlaquenil frontal fibrosing alopeciaSide effects of taking plaquenilOct appearance of plaquenil toxicity Compare Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil rated 6.8/10 in overall patient satisfaction. Plaquenil Compared to Alternatives - Plaquenil Compared to Alternatives -. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Discontinued Plaquenil.other options?. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.