Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Plaquenil dosages Plaquenil and feeling sick Chloroquine treatment I thought that plaquenil was more processed by the kidneys than the liver and the problem you describe is what my gi doc calls "dumping" when the liver can't handle the med and acts like its poison and you get explosive diarrhea as your body tries to get rid of it. Every medicine, vitamin, supplement that you take passes through the liver, including all the medicines you take Over-the-counter medicines; Prescription medicines; Vitamins; Dietary supplements; Alternative medicines; Your liver is responsible for processing all of these substances. As the drug is carried throughout the body, it can also negatively impact an organ, or organs, that is not the target organ the drug is intended to reach. 13 Before a drug can enter the central nervous system CNS–the brain and spinal cord– it must pass through the blood-brain barrier. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Is plaquenil processed through the liver Can plaquenil cause liver damage - Doctor answers on HealthcareMagic, Medications - American Liver Foundation. Your Liver. Your Life. Chloroquine induced cardiomyopathy Acetaminophen Tylenol Acetaminophen works well as a fever reducer and pain reliever but is one of the most common causes of medication-related liver failure. Of the liver failure cases attributed to medications, more than a third are due to acetaminophen. To prevent liver damage, make sure to limit your acetaminophen use to under 2 grams a day, and remember to read the ingredients on. The 10 Worst Medications for Your Liver - GoodRx. The Path Drugs Take Through the Body Sunrise House. The Risk of Retinal Toxicity with Plaquenil - Sjogren's. The liver is located in the upper right-hand portion of the abdominal cavity, beneath the diaphragm, and on top of the stomach, right kidney, and intestines. Shaped like a cone, the liver is a dark reddish-brown organ that weighs about 3 pounds. There are 2 distinct sources that supply blood to the. Plaquenil was originally approved by the Food and Drug Administration FDA in 1955. Plaquenil Warnings. Before taking Plaquenil, tell your doctor if you have or have ever had Liver disease. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal.