Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine reactive arthritis Clarithromycin and hydroxychloroquine lyme It is similar to hydroxychloroquine Plaquenil, and is useful in treating several forms of malaria as well as amebiasis that has spread outside of the intestines. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Plaquenil malaria mechanism Mechanism of action of hydroxychloroquine as an., Treatments for Rheumatoid Arthritis Chloroquine er derived vaculation Mechanism of action The mechanisms underlying the anti-inflammatory and immunomodulatory effects of Plaquenil are unknown. Indications and Usage for Plaquenil Malaria. Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. Plaquenil - FDA prescribing information, side effects and uses. Hydroxychloroquine decreases Th17-related cytokines in.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine is an antimalarial drug used to prevent and treat malaria. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine likely works in the prevention and treatment of malaria by interfering with the parasite's normal growth and replication process. Although the exact hydroxychloroquine mechanism of action is unknown when used to treat rheumatic diseases like rheumatoid arthritis, hydroxychloroquine inhibits communication between immune system cells.