Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can plaquenil cause edema Hydroxychloroquine retinitis pigmentosa Hydroxychloroquine for vasculities rash Hydroxychloroquine sulfate vs sodium bicarbonate Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Discolored patches on the skin are a common occurrence that most people will experience at some point in their lives. Skin discoloration can occur alongside other symptoms like itching, pain, and. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil skin discoloration Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine Side Effects Common, Severe, Long Term. Methotrexate and hydroxychloroquine side effectsCan you take zantac with plaquenilHow to take hydroxychloroquineAre mefloquine and plaquenil the samePlaquenil and atorvastatin Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Lesions resemble ecchymoses that fail to resolve, and drug extravasation and binding to melanin is a theorized mechanism. Some cases are. Treatment of hydroxychloroquine-induced hyperpigmentation of.. Discolored Skin Patches Pictures, Causes, and Treatments. Drug-induced hyperpigmentation DermNet NZ. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Importance Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms.