Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Chloroquine peak plasma concentrations Chloroquine treatment of cells Molecular Analysis for Therapy Choice MATCH Treatment Subprotocol H Phase II Study of Dabrafenib and Trametinib in Patients with tumors with BRAF V600E or V600K mutations excluding melanoma and thyroid cancer Pancreatic Cancer is an online community for sharing information about innovative, science-based treatments for pancreatic cancer. Please note that this information is not intended to be a substitute for professional medical opinion, advice, or diagnosis. Fig. 4 Treatment of a pancreatic cancer patient with trametinib plus hydroxychloroquine T/HCQ led to a reduction in tumor marker cancer antigen 19-9 CA19-9 and overall tumor burden. Data. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Trametinib hydroxychloroquine pancreatic cancer Trametinib and Hydroxychloroquine in Treating Patients With., Taking a Different Approach to Pancreatic Cancer Treatment. What is another name for plaquenil The combination of dabrafenib Tafinlar and trametinib Mekinist led to encouraging responses in patients with rare, incurable cancer of the digestive tract, according to phase II data presented. Dabrafenib Plus Trametinib Demonstrates Activity in GI Cancers. Protective autophagy elicited by RAF→MEK→ERK inhibition.. Trametinib and Hydroxychloroquine in Treating Patients with.. Hydroxychloroquine HCQ is an old FDA-approved drug used to treat malaria, and it inhibits autophagy. Based on this discovery and the drug’s availability, HCQ was tested in clinical trials for pancreatic cancer, but it did not have an impact when used alone. Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. O'Hara et al. reported the results from a phase II, single arm study in patients with metastatic colon cancer treated with hydroxychloroquine in combination with standard first-line chemotherapy mFOLFOX6 29.