This condition is called Post-Treatment Lyme Disease Syndrome (PTLDS). Some experts believe that can trigger an “auto-immune” response causing symptoms that last well after the infection itself is gone. Auto–immune responses are known to occur following other infections, including campylobacter (Guillain-Barré syndrome), chlamydia (Reiter’s syndrome), and strep throat (rheumatic heart disease). How often is plaquenil taken in the population Plaquenil brittle hair Although most cases of Lyme disease can be cured with a 2- to 4-week course of oral antibiotics, patients can sometimes have symptoms of pain, fatigue, or difficulty thinking that linger for more than 6 months after they finish treatment. This condition is called Post-Treatment Lyme Disease Syndrome PTLDS. MATERIAL/METHODS 235 patients with a multi-symptom complex typical of chronic Lyme disease, ie fatigue, musculoskeletal pain, and neurocognitive dysfunction and with serologic reactivity against B.burgdorferi were treated with a macrolide antibiotic eg clarithromycin and hydroxychloroquine. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Finally, some believe that the symptoms of PTLDS are due to other causes unrelated to the patient’s funded by the National Institutes of Health (NIH) have found that long-term outcomes are no better for patients who received additional prolonged antibiotic treatment than for patients who received placebo. Other experts hypothesize that PTLDS results from a persistent but difficult to detect infection. Hydroxychloroquine lyme treatment Lyme Disease Treatment & Management Approach Considerations., Macrolide therapy of chronic Lyme Disease. Mode of action of chloroquineChloroquine drug action Arthritis Rheum. 1981 Dec;24121567-9. Treatment of chronic Lyme arthritis with hydroxychloroquine. Coblyn JS, Taylor P. PMID 7326069 Treatment of chronic Lyme arthritis with hydroxychloroquine.. Hydroxychloroquine Plaquenil. Diagnosis and Treatment of Lyme Arthritis. Mar 16, 2009 I was just prescribed plaquenil to treat the cyst form of lyme. The usage of the drug says it is to suppress the immune system in the treatment of lupus. Why would you want to do this if you have lyme. I thought steriods and drugs that suppress the immune system make treatment much slower. Oct 06, 2017 User Reviews for Hydroxychloroquine to treat Lyme Disease, Arthritis. Also known as Plaquenil, Quineprox. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Overview; Side Effects; Dosage Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti- spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis.