Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. The researchers have found that a new combination therapeutic approach can effectively fight the disease and prolong survival among patients. Ic hydroxychloroquine Chloroquine and primaquine malaria Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. The therapy would use a combination of two FDA Food and Drug Administration approved drugs that are currently being used for other types of cancer – namely trametinib and hydroxychloroquine. Phase I Trial of Trametinib and Hydroxychloroquine in Patients With Advanced Pancreatic Cancer THREAD Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. The results of the study were published in the latest issue of the journal The team has opened up the therapy for clinical trials at HCI as well as other centres across United States along with support from University of California, San Francisco, and Columbia University in New York. The therapy has shown promise in the laboratory set up and now is ready for use among human patients in its clinical trials. Trametinib and hydroxychloroquine Trametinib and Hydroxychloroquine in Treating Patients With., New therapeutic approach for patients with pancreatic cancer Plaquenil 10 mgPlaquenil sulfate ค อIs plaquenil used for rheumatoid arthritisChloroquine and breast cancer Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Phase I Trial of Trametinib and Hydroxychloroquine in.. Dabrafenib, Trametinib and Hydroxychloroquine in Patients.. Addition of hydroxychloroquine is safe and tolerable with a modest improvement in clinical responses compared to prior studies. Autophagy inhibition may overcome chemotherapy resistance in advanced NSCLC and further study in a more molecularly selected population such as KRAS-positive tumors is warranted. Fig. 4 Treatment of a pancreatic cancer patient with trametinib plus hydroxychloroquine T/HCQ led to a reduction in tumor marker cancer antigen 19-9 CA19-9 and overall tumor burden. Trametinib is a dual-kinase inhibitor that is used in the treatment of advanced malignant melanoma, usually in combination with darbafenib. Trametinib therapy is associated with transient elevations in serum aminotransferase and alkaline phosphatase levels during therapy, but has yet to be linked cases of clinically apparent acute liver injury.