This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase. Possible side effects include diarrhea, vomiting, nausea, thrush, and skin rash. As with all antimicrobial agents, antibiotic-associated diarrhea due to Clostridium difficile infection—sometimes leading to pseudomembranous colitis—may occur during or after treatment with amoxicillin/clavulanic acid. Rarely, cholestatic jaundice (also referred to as cholestatic hepatitis, a form of liver toxicity) has been associated with amoxicillin/clavulanic acid. The reaction may occur up to several weeks after treatment has stopped, and usually takes weeks to resolve. It is more frequent in men, older people, and those who have taken long courses of treatment; the estimated overall incidence is one in 100,000 exposures. Amoxicillin/clavulanic acid is the International Nonproprietary Name (INN) and co-amoxiclav is the British Approved Name (BAN). Many branded products indicate their strengths as the quantity of amoxicillin. viagra 25mg reviews This sheet talks about exposure to Amoxicillin and Clavulanate in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider. This combination medication is an antibiotic used to treat a variety of bacterial infections. It is a combination of amoxicillin, a penicillin-like antibiotic, and clavulanate, a drug that increases the effectiveness of amoxicillin. Brand names include Amoclav®, Augmentin XR® and Clavamox®. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. Most studies have not found an increased chance for birth defects when amox/clav is taken during the first trimester; however, there are very few studies available. There are more studies looking at the use of amoxicillin alone during pregnancy. Buy clomid in usa Is it legal to buy viagra in bali Antabuse death A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays. cialis works Sep 1, 2018. This sheet talks about exposure to Amoxicillin and Clavulanate in pregnancy and while breastfeeding. This information should not take the. The combination of amoxicillin and clavulanate is an oral antibiotic widely used in the. Katsinelos P, Vasiliadis T, Xiarchos P, Patakiouta F, Christodoulou K. Β-lactamase−producing strains of Haemophilus influenzae and Moraxella catarrhalis Mild to moderate: 500/125 mg PO q12hr or 250/125 mg PO q8hr for 10 days Severe: 875/125 mg PO q12hr or 500/125 mg PO q8hr or 2000 mg (2 extended-release tabs) PO q12hr for 7-10 days Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Dysphagia: May substitute 250 mg/5 m L suspension for 500/125 mg tablet; may substitute 200 mg/5 m L or 400 mg/5 m L suspension for 875/125 mg tablet Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs Hypersensitivity reactions Anaphylaxis Anemia Thrombocytopenia Leukopenia Agranulocytosis Hepatoxicity AST/ALT elevation Pseudomembranous colitis Serum sickness Abdominal discomfort Cholestatic jaundice Flatulence Allergy to cephalosporins, carbapenems Different tablets are not interchangeable, because ratios of amoxicillin to clavulanate are different Extended release tablets not for use in renal impairment (Cr Cl Amoxicillin binds to penicillin-binding proteins, thus inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of clavulanate inhibits beta-lactamase-producing bacteria, allowing amoxicillin extended spectrum of action It is a semisynthetic antibiotic with a broad spectrum of bactericidal activity, covering both gram-negative and gram-positive microorganisms Not effective against Mycoplasma and Legionella spp Peak plasma time: 2 hr (amoxicillin); 1.1 hr (clavulanic acid) Peak concentration: 8-22 mcg/m L (amoxicillin); 0.8-2.6 mcg/m L (clavulanic acid) AUC: 40-80 mcg•hr/m L (amoxicillin); 2-6 mcg•hr/m L (clavulanic acid) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Amoxicillin clavulanate is an important and effective medicine but its use must be reserved for specific indications in order to reduce the rate of antimicrobial resistant infections. First-line indications for amoxicillin clavulanate are; mammalian bites (including human), diabetic foot infections and periorbital/facial cellulitis. Hepatitis and cholestatic jaundice have been reported with the use of amoxicillin clavulanate. It appears that this adverse effect can occur during treatment or up to six weeks after treatment cessation. Increasing age, prolonged treatment and male gender are risk factors. Cholestatic jaundice occurs in approximately 1 in 6000 patients. Acute liver toxicity occurs in people taking amoxicillin clavulanate at six times the rate of people taking amoxicillin. 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It works by stopping the growth of bacteria.